HeDWIC capitalizes on decades of research in plant stress as well as the emergence of new technologies to advance the frontier of breeding. For example, wheat researchers have identified biological mechanisms that enable the crop to cool itself under heat stress, root systems that mine deep water under drought, and wild relatives that can withstand very high temperatures. With advancements in high-speed computing, remote sensing, and genomic technologies, we can, for the first time, apply this knowledge to develop new climate-resilient wheat varieties.